Description
Potent irreversible alphaVbeta3 integrin antagonist (Ki = 0.27nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, alphaIIbbeta3) receptors (IC50 = 30nM) in vitro